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Medical Discovery

Small Game Hunting: Microbial Diagnostics, Surveillance and Discovery in Acute and Chronic Diseases

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W. Ian Lipkin, MD
John Snow Professor of Epidemiology
Director, Center for Infection and Immunity
Mailman School of Public Health
Professor of Pathology and Neurology
College of Physicians & Surgeons, Columbia University

How do we track the emergence or re-emergence of an infectious disease? Recent advances in molecular and computational methods have greatly increased the global capacity for effective surveillance of infectious diseases in humans, wildlife, and domestic animals. These technological breakthroughs have also accelerated the pace of discovery in studies of microbial communities that live in our bodies and their roles in chronic illness and health. Professor Lipkin, who served as chief scientific consultant for the Hollywood film, “Contagion,” will describe the promises and pitfalls facing a 21st century microbe hunter, drawing from his experience performing basic research, responding to emerging infectious threats and communicating science to the public.

The Center for Genetic Medicine Silverstein Lecture Series was established by the Herman M. and Bea L. Silverstein Medical Research Fund for Genetic Medicine to bring advances in genetics research and medicine to the general public.

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Medical Discovery

Antibodies Against Ebola and Lassa: A Global Collaboration

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Joseph J. Kinyoun Memorial Lecture – Antibodies Against Ebola and Lassa: A Global Collaboration

Air date: Tuesday, December 5, 2017, 3:00:00 PM

Category: Joseph J. Kinyoun – Infection and Immunity

Runtime: 00:52:54

Description: Joseph J. Kinyoun Memorial Lecture 2017

Dr. Erica Ollmann Saphire, director of the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC), will deliver the 2017 Joseph J. Kinyoun Memorial Lecture.

Her talk, “Antibodies Against Ebola and Lassa: A Global Collaboration,” will explore the features of antibodies that protect against these deadly viruses and the ongoing need for scientists to collaborate in this research to establish a complete knowledge base. During the past three years, VIC researchers from dozens of labs on five continents have studied these protective antibodies. The VIC aims to fill critical knowledge gaps and provide a foundation of research that can be used to improve existing vaccines and antivirals, and to evaluate the pipeline of candidate countermeasures.

Ollmann Saphire, who has served as VIC director since 2013, investigates the structural biology of both viruses and antibodies—how viruses like Ebola, Marburg and Lassa infect host cells, what the viruses’ weaknesses are, and which antibody combinations might defeat them. This work has led to surprising and substantial discoveries in virology: Her team recently discovered that some viral proteins can change their 3D structures to play several different roles, allowing more information and more function to be encoded in concise viral genomes.

Ollmann Saphire received her Ph.D. in Macromolecular and Cellular Structure and Chemistry from The Scripps Research Institute (SRI) in 2000. She has since held a number of positions at TSRI, where she is currently a professor of Immunology and Microbial Science. Her work has been recognized with a Presidential Early Career Award for Scientists and Engineers by the Burroughs Wellcome Fund, and young investigator awards from The American Society for Biochemistry and Molecular Biology, the American Society for Microbiology, and the International Society for Antiviral Research. She is a fellow of both the American Academy of Microbiology and the American Association for the Advancement of Science, and serves on the Scientific Leadership Board of the Global Virus Network.

Since 1979, NIAID has hosted an annual public lecture in honor of Dr. Joseph J. Kinyoun. In 1887, Kinyoun founded the Laboratory of Hygiene—the forerunner of NIH—paving the way for more than a century of groundbreaking medical discoveries since then.

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Author: Erica Ollmann Saphire, Ph.D., Director, Viral Hemorrhagic Fever Immunotherapeutic Consortium

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Medical Discovery

Our Holographic Universe Will be the Greatest Discovery of All Time l Update Prophecy TV

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Our Holographic Universe Will be the Greatest Discovery of All Time l Update Prophecy TV
Our Holographic Universe Will be the Greatest Discovery of All Time l Update Prophecy TV
There is enormous proof that our universe is holographic, if true it’ll be the strangest medical discovery of all time. It is now becoming clear that searching at phenomena via a holographic lens may be key to solving a number of the most confusing problems in physics. Physicists currently presented the clearest evidence yet that our Universe could be just one huge projection.

The universe present as a ‘hologram’ is the idea that the 3 dimensions we understand are sincerely simply “painted” onto the cosmological horizon – the boundary of the recognised universe.

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Medical Discovery

SBP’s Dr. Aman Mann on Alzheimer’s discovery

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Dr. Aman Mann of the Sanford Burnham Prebys Medical Discovery Institute discusses a finding that may lead to earlier detection and treatment of Alzheimer’s disease.

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