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New Model for Alzheimer’s, pt 2 – FORD BREWER MD MPH

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FORD BREWER MD MPH PrevMedHeartRisk.com
To prevent disability, heart attack, stroke, dementia – visit my Youtube Channel at

Or the PrevMed web site at

The NIA (National Institute of Aging) and AA (Alzheimer’s Association) recently formed another policy group. The purpose is to include the biomarkers and new biological models in research and disease development.

This is the citation for the NIH announcement of the new group.

This is the editorial describing the impact of the new group.

Recognized biomarkers include beta amyloid and tau. It’s recognized now that these happen 20 years earlier than the dementia.

Comorbidities or related diseases include PART (Primary Age Related Taupathy), ARTAG (Age Related Tau Astroglipathy), and CART (Cerebral Age Related TDP-43 with Sclerosis)( also known as hippocampal sclerosis).

About Dr. Brewer – Dr. Brewer started as an Emergency Doctor. After seeing too many patients coming in dead from early heart attacks, he went to Johns Hopkins to learn Preventive Medicine. He went on to run the post-graduate training program (residency) in Preventive Medicine at Hopkins. From there, he made a career of practicing and managing preventive medicine and primary care clinics. His later role in this area was Chief Medical Officer for Premise, which has over 500 primary care/ prevention clinics. He was also the Chief Medical Officer for MDLIVE, the second largest telemedicine company. More recently, he founded PrevMed, a heart attack, stroke, and diabetes prevention clinic.
At PrevMed, we focus on heart attack, stroke, disability, cancer and Alzheimer’s prevention. We find a lot of undiagnosed Type 2 diabetes. Treating unrecognized risk factors like diabetes allows reduction of risk. We provide state-of-the-art genetic testing, imaging, labs and telemedicine options. We serve patients who have already experienced an event as well as those have not developed a diagnosis or event. Our team of senior clinicians includes internationally recognized leaders in the research and treatment of cardiovascular disease, preventive medicine and wellness. We also provide preventive medicine by telemedicine technology to over 30 states. Contact Dr. Brewer at info@prevmedheartrisk.com or visit

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4 Comments

4 Comments

  1. John Lorscheider

    June 6, 2018 at 8:21 pm

    In addition to A+T+(N)+, development of Alzheimer's and other forms of dementias can also be influenced by vascular risk factors, such as hypertension, coronary artery disease, diabetes, insulin resistance, and hyperlipidemia. These vascular factors increase the risk of AD occurrence.

    "Cerebral small vessel disease and Alzheimer’s disease" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629951/

  2. Akane Cortich

    June 7, 2018 at 1:33 am

    Thanks for this. I have dealt with a few people with very advanced AD. It is both confronting, incredibly strange, sometimes comical, and always sad. But as we are seeing we can maybe avert many of the risks through dietary choices – if we are willing to adopt them in time.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717030/
    The current article discusses nutritional factors, including the benefits of adopting a calorically appropriate, low-carbohydrate, adequate protein and fat containing diet which appear to be the best way to prevent and/or delay the progression of both periodontal disease and AD. Virgin coconut oil and MCTs supplements provide ketone bodies which can support the brain, and help to improve oral microbiota. The current article also discusses multiple shared risk factors of periodontitis and AD in relation to their co-morbid status development. One important dental aspect highlighted at least a decade ago, but taken little notice of, is how fewer teeth alter people’s eating habits and their dietary choices, which impacts on oral, metabolic, GI tract and brain health. In the context of a multifactorial intervention (MEND™ programme), a lower carbohydrate diet supplemented with virgin coconut oil or MCT-Oils, fish or omega-3 fatty acids, selected nutrients or phytochemicals along with, for example, improvements in oral hygiene and sleep were necessary to improve oral health. These have already shown promise in delaying and even reversing symptoms of mild cognitive decline and AD (Bredesen, 2014; Bredesen et al., 2016). In conclusion, more research is needed to evaluate the effectiveness of diet-based interventions in supporting oral health, and to assess the potential impact of nutrition on AD onset and progression.

    Coconut Oil Attenuates the Effects of Amyloid-β on Cortical…. Available from: https://www.researchgate.net/publication/258035377_Coconut_Oil_Attenuates_the_Effects_of_Amyloid-b_on_Cortical_Neurons_In_Vitro [accessed Jun 07 2018].
    Abstract
    Dietary supplementation has been studied as an approach to ameliorating deficits associated with aging and neurodegeneration. We undertook this pilot study to investigate the effects of coconut oil supplementation directly on cortical neurons treated with amyloid-β (Aβ) peptide in vitro. Our results indicate that neuron survival in cultures co-treated with coconut oil and Aβ is rescued compared to cultures exposed only to Aβ. Coconut oil co-treatment also attenuates Aβ-induced mitochondrial alterations. The results of this pilot study provide a basis for further investigation of the effects of coconut oil, or its constituents, on neuronal survival focusing on mechanisms that may be involved.

  3. mikenagoya

    June 7, 2018 at 3:46 am

    Ford Brewer, MD. Sound coming through nice and clear on my basic laptop speakers, don't worry about 'hifi', we look forward to your content 🙂 And, as usual, it was very interesting. I can say on the subject of memory, my short term, as in, did I put the milk back in the fridge – example, has improved since making changes in my life style. First was to be more active, second; eat much less carbs and higher fat content food (HFLC) and third pay much closer attention to nutrition using the https://cronometer.com. All the best M.

  4. Ellen K

    June 8, 2018 at 12:00 pm

    Hi Dr. Brewer; can I pose a hypothetical here, and perhaps get an opinion? If a person (60, Psoriatic Arthritis and PBC and using CPAP at night, but otherwise healthy (ish) ) has had two TIAs in a month, and has been taking Vitamin K for about 6 months for the benefit to their bones and arteries (big family history of heart attacks), could, possibly, (a) the clearing of placque from the arteries have caused whatever (clot?) caused the TIA, and/or (b) just the Vit. K itself (about 200 mg daily) caused too much coagulation and be the culprit? If MRI and angiograms and other tests have shown nothing definitively, should this person just stop the k entirely and to hell with their arteries? That is what they're doing currently, anyway. They eat their greens, but not vegetarian or anything like that. Low dose aspirin daily is all that has been prescribed so far. And is 80 mg. once a day enough or might it be taken more than once per day, as it's such a small dosage?
    Again, all hypothetical and just wondering….If you cannot say, I understand, and anything you actually can suggest would be greatly appreciated. (It's always something….)

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