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Breakthrough Science

James P. Allison – Jessie Stevenson Kovalenko Medal

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April 29, 2018 – Allison’s pioneering research has had a vast impact on cancer therapy and the evolution of the entire field of cancer immunology. His work has advanced science while improving the health and wellbeing of cancer patients worldwide, a process that continues to this day.

This path began in 1983 when Allison reported on the protein structure of T cell receptor, providing one of the earliest looks at the molecules involved in T cell function. This led to the discovery of two molecules related to the activation of T cells, CD28 and CTLA-4, the second of which functions as an inhibitor that restricts T cell responses. In 1996 Allison showed that blocking CTLA-4 led to tumor rejection in mice. This opened up the field of “immune checkpoint therapy,” a paradigm shift in cancer treatment which targeted the immune system rather than tumors themselves.

After several years of clinical trials, CTLA-4 was approved as a standard treatment for patients with metastatic melanoma. It is currently being tested in several additional forms of tumors and has already benefited the lives of tens of thousands of patients.

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Breakthrough Science

Get Codes for your favorite sites ! – alternative future of europe

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Generate Get Codes for your favorite sites ! +-+-+-+- alternative future of europe woodinville (city/town/village) macross delta song axia batman begins …

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Breakthrough Science

Search for life beyond Earth | Alfonso Davila at Breakthrough Discuss 2018

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There are several candidates for life in the solar system, from traditional favourites like Mars to new contenders like icy moons of the outer planets. Here Alfonso takes a step back to look at the scientific reasoning behind choosing and investigating these targets, arguing that exploration-driven approaches should give way to hypothesis-driven science

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Breakthrough Science

EaPEC2017: Enlighten Your Research awards – full session

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One of the highlights of the 2nd Eastern Partnership E-infrastructures Conference (EaPEC2017) was the presentation of the Eastern Partnership region’s first ‘Enlighten Your Research’ (EYR) awards. The EYR programme invites researchers to submit proposals that highlight how access to advanced networks, technologies and computation would significantly improve their research and discovery process. Presenting the awards to the first regional EYR winners, Mary Hester of SURFnet explained the evolution of the programme since its start in the Netherlands in 2007. Six winning proposals ranged from high performance computing to open data projects:
• Tigran Zargaryan, National Library of Armenia for “Online Armenian digital library for research based on the e-infrastructure facilities of the National Academy of Sciences of Armenia”.
• Igbal Safarov, University of Utrecht, the Netherlands for “Open Government Data adoption: A multi-level framework for data sharing and utilization in EaP countries”.
• Grusha Alexander Ivanovich, Central Scientific Library Yakub Kolas of the National Academy of Sciences of Belarus for “Heritage Digital Data”.
• Boris Hincu & Elena Calmis, Moldova State University for “Elaboration of the Task Oriented Instrumental Support (TOIS) for Integration of MSU and IMI HPC Clusters into a Cloud Computing System”.
• Maryna Druchenko, Scientific and Technical Library, National Technical University of Ukraine for “KPI Digitization Center: Center for digitization of cultural heritage for the Ukrainian libraries, museums and archives”.
• Yevhen Plotnikov, Nizhyn State University named after Mykola Gogol for “Through Research to Perfection: New Approaches to Continuous Professional Development of In-Service Teachers”.

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